Urolithiasis is one of the serious renal disorder that require a well targeted therapeutic strategy. Number of drugs are available for the treatment of lithiasis, but clinical evaluation of these drugs has shown incidences of relapses, side effects and drug interactions. This has been the rational for the development of new anti-urolithiatic drugs and search for novel molecules. Also assumed that, if the remedy from herbal source that offer better protection and decreased relapse, because they promote the repair mechanism in natural way. After a survey, leaves of Cucumissativus were selected for the present study. Aqueous and alcoholic extract of leaves of C.sativus was screened for its antiurolithiatic activity by in vitro model. Aqueous extract showed significant antiurolithiatic activity when compared to the reference standard (Cystone).

Ethanolic extracts from leaf of Datura inoxia and Withania somnifera of family solanaceae were evaluated for potential antifungal activity against fungal pathogens of vegetable beans. The present study is aimed at evaluating the in-vitro antifungal activity of ethanolic extracts of solanaceae plants against Alternaria alternata, Fusarium pallidoroseum, Curvularia lunata and Macrophomina phaseolina. These plants can further be used in folk medicine to determine their antifungal activity against fungal pathogens of vegetable beans. These plants extracts can possibly be exploited in the management of fungal diseases of vegetable beans in an eco-friendly way.

Molecular docking is a bioinformatics tool used to study and analyse ligand receptor interactions. This helps in identifying the receptors (molecular targets) for different ligands. Using these technologies, compound isolation and drug discovery from herbals is achieved. Herbs are widely used in treatment of various ailments from time immemorial. Phytochemists and drug developers are now interestingly working in developing new molecules that can act effectively than conventional drugs. As they are developing it mostly from herbs they are found to be effective and safer drugs and quantity to be used become minimum. Crateva magna Lour. (DC.) is a plant distributed widely in India and used for urinary disorders. The plant bark was extracted and studied for its active compounds that possess antiurolithiatic activity. After performing various preliminary phytochemical studies and applying chromatographic methods, molecular docking was carried out with isolated bioactive compound and Tamm–Horsfall protein (THP). By docking analysis the bioactive compound 14-hydroxy-12-abietene-7-one interacted with THP and it may inhibit calcium oxalate crystallization.

Breast cancer is a malignant cancer that start in the cells of breast and a lump is formed in the breast. Cancerous cells start to begins in the cells of lobules and in other tissues of breast but later on cells can travel to other parts of body through lymphatic system. Due to lump formation size of breast changes, it can be due to many reasons like obesity, lack of physical exercise, drinking alcohol and mainly hereditary. According to that pepper by giving to breast cancer patients for prevention After questioning 1,945 women with early-stage invasive breast cancer, recently researchers found that 45% reported at least one toxicity-related side effect they ranked as either ‘severe’ or ‘very severe’, Nearly half of women being treated for early-stage invasive breast cancer report suffering ‘severe’ or ‘very severe’ side effects from their drugs, Irregular lump in one or both breasts, Swelling of all or part of the breast, even if no lump is detected, Skin irritation or dimpling, Pain in the breast or nipple, Nipple retraction (nipple turning inward), Nipple discharge (other than breast milk), pain in armpits, redness of skin, sometimes nipples may discharge blood, size of breast increases. Breast Cancer prevention is the diet provides an example of a full day’s healthy diet, inspired by Asian countries, Prevention is always better than cure. Therefore, the focus of the meals are on foods that reduce the risk of getting breast cancer or, if the person has already been diagnosed with it, foods that reduce its recurrence. Foods that have been shown to have this potential include cruciferous vegetables, black pepper and foods with soluble fiber, Piperine reduces the growth of breast cancer cells without affecting the growth of normal breast cells. Piperine has been shown to inhibit the growth and motility of triple negative breast cancer cells.

Alcoholic and aqueous extract of aerial parts of Corallocarpus epigaeus (CE) were prepared and given orally at different doses to different groups of rats fasted for 18 h (both normal and streptozotocin (STZ) induced diabetic rats). The serum glucose levels were measured initially at 0 h and at 0.5,1,2,3,4,6,8,12,16,20 and 24 h after the treatment. The alcoholic extract of aerial parts of C.epigaeus (AEACE) at medium dose (200 mg/kg) and higher dose (400 mg/kg) produced maximal serum glucose lowering effect in both normal and STZ induced diabetic rats. The aqueous extract of aerial parts of C.epigaeus (AQEACE) produced maximal percent reduction in serum glucose levels at higher dose (400 mg/kg) both in normal and STZ induced diabetic rats. AEACE and AQEACE produced biphasic response with peak hypoglycemic and antidiabetic activities recorded out at 4 h and 8 h intervals in a dose dependent manner, the effect was found to be better than that of standard gliclazide (2 mg/kg) an oral hypoglycemic agent.

In this study the pharmacognostical parameters for the tuberous roots of the plant Corallocarpus epigaeus (Cucurbitaceae) were evaluated. Traditionally the plant is used as bitter, emetic, cures inflammations (Ayurveda). Root tuber for snake bite, anaemia, leprosy, eczema, dysentery, arthitis, rheumatism, chronic mucous enteritis, diabetes. Stem for filariasis, wounds, emetic, goiter and diabetes. An attempt has been made for proper identification of this folk herb for obtaining its complete therapeutic effects. In this context the morphoanatomy of tuberous roots along with, microscopic linear measurements, WHO recommended physico-chemical determinations and authentic phytochemical procedures, are the important diagnostic characters have been carried out to aid the complete pharmacognostical evaluation of the plant. The parameters reported in this paper may be proposed as the referential standards to establish the authenticity of Corallocarpus epigaeus. This study also helps in differentiation of this drug from its other species.