Tuberculosis (TB) is one of the top 10 causes of death worldwide in 2015 with an estimated 10.4 million incident cases globally. The objective of this study was to evaluate the effect of ‘COPPS’, a formulation made from Curcuma longa, Ocimum sanctum, Piper nigrum and Plectranthus amboinicus on the nutritional and health status of subjects with active pulmonary tuberculosis on DOTS therapy. Six among the 9 subjects in the study, were severely malnourished, 6 had low albumin levels and 8 had elevated C- reactive protein levels. All of them had adverse GI symptoms. After intervention for 45 days, the mean increase in BMI (1.79 ± 0.784 kg/m2), weight gain (10.92 ± 5.04 %) and reduction in C-reactive protein (-26.32 ± 25.1 mg/L) and ESR (-27 ± 18 mm/hr) were seen in 5 subjects. The use of COPPS was successful in the reducing the adverse gastrointestinal symptoms, but the complementary effect in reducing infection and inflammation needs further research.

Microencapsulation is the expansion of all-encompassing one substance within another substance on a very small scale, yielding capsules ranging from less than 1-100µ in size. The encapsulation efficiency of the microcapsule depends upon different factors like concentration of the polymer, solubility of polymer in solvent, rate of solvent removal, solubility of organic solvent in water etc. Microencapsulation may be achieved by a innumerable of techniques. Microencapsulation of gear could also be with the aim that the core material be confined at intervals capsule walls for a particular amount of your time. On the opposite hand, core materials could also be encapsulated in order that the core material are discharged either bit by bit through the capsule walls, called controlled unleash or diffusion, or when exterior situation activate the capsule walls to rupture, melt, or dissolve.

Hepatic diseases square measure turning into one in every of the few diseases that can't be effectively cured because of some reasons though numerous receptors existed within the liver. Currently, many passive targeting delivery systems are utilized in the drug/gene delivery for the treatment of internal organ diseases. More significantly, completely different measures would be taken in unison to the desired cell that was lesioned or dysfunctioned via interaction between orienting ligands and target receptors therefore on improve accumulation of medication within the target cell and to cut back nonspecific toxicity towards alternative cells or organs. Many serious liver diseases affecting millions of people world-wide cannot be treated despite many efforts which warrant a search for new therapeutic strategies. Potent medicine might not be effective enough in-vivo or exhibit adverse effects and increased delivery into the target cells could improve this considerably. We aim to summarize the offered choices for drug delivery to the various intrahepatic cell-types.

Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge number of populations in the world. It was mainly characterized by chronic hyperglycemia, resulting from defects in insulin secretion or insulin action. Even though the cases of diabetes are increasing by except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so far. The review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used now days. Streptozotocin and alloxan are mainly used for evaluating the ant diabetic activity of a particular drug. This review contain list of medicinal plants which have been tested for their ant diabetic activity in the streptozotocin induced diabetic rat model. Thus, the information provided in this review with help of researchers for the development of an alternative methods rather than insulin and oral hypoglycemic agents for the treatment of diabetes mellitus, which will minimize the complication associated with the diabetes and related disorder.

Scleropyrum pentandrum (Dennst.) Mabb is a member of family santalaceae. This is a small tree of evergreen forests of different parts of the world. It is found in sandy soil of Peninsular India, Western Ghats, South and Central Sahyadris and divine forests of coastal Kerala. Traditionally Scleropyrum pentandrum is important in different biological activities and tribal community across the world is exploring the benefit of this medicinally important plant. This present study explains the anthelmintic activity of the stem of the Scleropyrum pentandrum. The aqueous and alcoholic extracts of the stem were tested for its anthelmintic activity. The positive results obtained direct the necessity of further study. The chemical identity of various components must be done by isolating and elucidating its medicinally active constituents. Necessary studies are needed to evaluate each compound for its pharmacological identities.