Background: Frequent consumption of western diet containing saturated fatty acids and increase risk of metabolic syndrome (MS). Features of MS include visceral obesity, insulin resistance, dyslipidemia, cardiovascular complication and hypertension. The aim of this study was to investigate the role of Nigella sativa and ginger in ameliorating features of MS. Methods: Induction of MS in rats by high‐fructose high‐fat fed diet was certain after 8 weeks. Animals were alienated into four groups: normal control, MS control group given saline, MS groups given fenugreek oil (4 ml/kg), and omega-3 (260 mg/kg) daily for 4 weeks. Parameters chosen for assessment included effect on body weight gain, glucose, insulin, adiponectin levels, and lipid profile. Also, peroxisome proliferator‐activated receptor‐gamma (PPARγ) protein expressions and glucose transporter 4 (GLUT4) content were estimated. In addition, Blood pressure, heart rate, CK-MB, and LDH were estimated. Also renal function tests and antioxidant activity were evaluated. Additionally, CRP, and fibrinogen were determined. Results: Fenugreek oil and omega-3 caused decrease in both MS‐induced increase in body weight and glucose. They reduced insulin level and resistance with increased adiponectin, and correction of MS‐induced hyperlipidemia. Drugs also increased GLUT4 and PPARγ protein expression compared with MS control group. Furthermore, both drugs caused decrease in both MS‐induced increase in blood pressure and heart rate. They reduced creatinine, BUN, uric acid, albumin, and MDA with increased GSH, and SOD. Also, both fenugreek and omega-3decreased CRP, and fibrinogen compared with MS control group. Conclusion: Fenugreek oil and omega-3ameliorate cardiac and renal complication of MS via their antioxidant activity and increase in GLUT4 and PPARγ expression.

In this study plants gathered from extraordinary areas of India were screened to pick out any chemotherapeutic agents present in them. Different solvent likePet.ether, Chloroform, Methanol and distilled waterextracts of antipyretics and antitumor activity the use of Induction of yeast-induced pyrexia, potato disc assay, and phytotoxicity interest the use of radish seed bioassay. Phytochemical tests confirmed the whole plants presence of alkaloids, saponines, anthraquinones, terpenoids, flavonoids, flavones, tannins, phlobatannins, and cardiac glycosides in distinctive concentrations in these extracts. The present review is therefore, an effort to give a detailed survey of the literature on its Pharmacognosy, Phytochemistry, pharmacological and traditional uses.

Objective: The present study was aimed to prepare various formulations, evaluate the antimicrobial efficacy, safety and stability of the prepared formulations and to standardize the formulations by various methods.Methods: The leaf and bark of the plants Cassia fistula, Milletia pinnata, Ficus religiosa and Wendlandia thyrsoidea were extracted and screened for antimicrobial activity. The active extracts were used to prepare eight formulations. They were Cream, gel, hand wash, sanitizer, soap, tooth paste, tooth powder and mouth wash. The formulations were subjected to antimicrobial and phytochemical screening. The total phenolic and condensed tannin contents were evaluated. The HPLC and HPTLC fingerprinting was done using tannic acid and gallic acid as standards. The formulations were further subjected to skin toxicity studies on albino rats in order to evaluate the safety. Accelerated stability studies were done by exposing the formulations to variations in temperatures and evaluating the physico-chemical parameters for 120 days. Results: The methanolic bark extracts exhibited good antimicrobial properties. Phytochemical screening of the formulations revealed the presence of tannins and polyphenols. The HPLC and HPTLC fingerprinting exhibited peaks corresponding to the retention times and Rf values of the standards. Results of animal studies revealed that they were safe and did not produce any inflammation and oedema after 7 days. Accelerated stability studies confirmed that the formulations were found to be stable.Conclusion: The formulations were safe with good antimicrobial effects and they were found to be stable after 120 days of stability studies.

Current trials to the treatment of coronavirus disease 2019 should open new prospects in the search for novel drugs from medicinal plants and other natural products. This paper provides details of some nutraceuticals that inhibit human coronavirus entry into cells, general replication, and specific chymotrypsin-like protease (3CLpro)-mediated replication. Many non-pharmaceutical interventions were approved by countries worldwide in the fight against the COVID-19 pandemic with adverse socioeconomic side effects, which raises the question about their differential effectiveness. We estimate the effect of each intervention on the incidence of COVID-19. In recent years, there has been a growing interest in nutraceuticals, which are those nutrients in foods that have beneficial effects on health. There has been extensive interest in the antiviral properties of nutraceuticals, which are especially topical in the context of the ongoing COVID-19 pandemic. The Prophet Mohamed may God’s prayers and peace be upon him, came with the religion and assistance to the world as he urged what is in the benefit of the bodies and prohibited everything that spoils them, so he commanded and desired medication. Many quranic verses in the Book of God Almighty talk about the bliss of paradise and what God has prepared for his pious servants. Therefore, the aim of this review is to evaluate the main nutraceuticals to which antiviral roles have been attributed (either by direct action on viruses or by modulating the immune system), with a focus on what was mentioned in the Holy Quran and Sunnah. Furthermore, the possible use of these substances against SARS-CoV-2.

The present work was investigates that enhancement of dissolution profile of Ziprasidone by using super disintegrants like croscaramellose sodium and sodium starch glycolate. Ziprasidone fast disintegrating tablets (FDT) can be prepared direct compression method. Effect of disintegrants on disintegration and dissolution parameters were studied. Disintegrating time and dissolution parameter (T50% and T90%) decreased with increases in the level of croscarmellose sodium and sodium starch glycolate. It was concluded that the ZF6 formulation with croscaramellose sodium (6%) as super disintegrating agent shows good drug release on ziprasidone tablet formulation.